SIDE EFFECTS MAY OCCUR WHILE TAKING KEYTRUDA

During treatment with KEYTRUDA, side effects can occur and should be treated as early as possible. In clinical trials with KEYTRUDA, some patients stopped treatment due to side effects. Tell your doctor if you have any side effect that bothers you or that does not go away.

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Serious side effects

KEYTRUDA is a medicine that may treat your melanoma by working with your immune system. KEYTRUDA can cause your immune system to attack normal organs and tissues in many areas of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death.

Call or see your doctor right away if you develop any symptoms of the following problems or these symptoms get worse:

  • Potential Adverse Reactions to KEYTRUDA Include Lung Problems (pneumonitis)

    Lung problems (pneumonitis)

    • Shortness of breath
    • Chest pain
    • New or worse cough
  • Potential Adverse Reactions to KEYTRUDA Include Intestinal Problems (colitis)

    Intestinal problems (colitis) that can lead to tears or holes in your intestine

    • Diarrhea or more bowel movements than usual
    • Stools that are black, tarry, sticky, or have blood or mucus
    • Severe stomach-area (abdomen) pain or tenderness
  • Potential Adverse Reactions to KEYTRUDA Include Liver Problems (hepatitis)

    Liver problems (hepatitis)

    • Yellowing of your skin or the whites of your eyes
    • Nausea or vomiting
    • Pain on the right side of your stomach area (abdomen)
    • Dark urine
    • Feeling less hungry than usual
    • Bleeding or bruising more easily than normal
  • Potential Adverse Reactions to KEYTRUDA Include Hormone Gland Problems (especially the thyroid, pituitary, adrenal glands, and pancreas)

    Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas)

    • Rapid heart beat
    • Weight loss or weight gain
    • Increased sweating
    • Feeling more hungry or thirsty
    • Urinating more often than usual
    • Hair loss
    • Feeling cold
    • Constipation
    • Your voice gets
      deeper
    • Muscle aches
    • Dizziness or fainting
    • Headaches that will not go away or unusual headache
  • Potential Adverse Reactions to KEYTRUDA Include Kidney Problems

    Kidney problems, including nephritis and kidney failure

    • Change in the amount or color of your urine
  • Potential Adverse Reactions to KEYTRUDA Include Problems With Other Organs

    Problems in other organs

    • Rash
    • Changes in eyesight
    • Severe or persistent muscle or joint pains
    • Severe muscle weakness
    • Low red blood cells (anemia)
  • Potential Adverse Reactions to KEYTRUDA Include Infusion (IV) Reactions

    Infusion (IV) reactions that can sometimes be severe or life‑threatening

    • Chills or shaking
    • Shortness of breath or wheezing
    • Itching or rash
    • Flushing
    • Dizziness
    • Fever
    • Feeling like passing
      out

Getting medical treatment right away may help keep these problems from becoming more serious. Your doctor will check you for these problems during treatment with KEYTRUDA. Your doctor may treat you with corticosteroid or hormone replacement medicines. Your doctor may also need to delay or completely stop treatment with KEYTRUDA, if you have severe side effects.

Common side effects

Common side effects of KEYTRUDA include: feeling tired, itching, diarrhea, decreased appetite, rash, shortness of breath, constipation, and nausea.

These are not all the possible side effects of KEYTRUDA. For more information, ask your doctor or pharmacist. Tell your doctor if you have any side effect that bothers you or that does not go away.