KEYTRUDA® (pembrolizumab) for Advanced Cervical Cancer May Be
                                        Right for You
Advanced cervical cancer

IS KEYTRUDA RIGHT FOR YOU?

KEYTRUDA may be part of your treatment plan

No one is prepared to hear the word cancer. Learning more about your diagnosis and treatment can make a difference. The information below can help you understand how your treatment works and provide questions to ask your care team. Remember, you have a voice in your care.

Talk to your doctor about your treatment options for advanced cervical cancer.

If your tumor tests positive for "PD-L1," your doctor may consider:

Learn About KEYTRUDA® (pembrolizumab) With Combination Therapy as a First Treatment Option for Your Cervical Cancer

KEYTRUDA + combination therapy as a first treatment when your cervical cancer does not go away (persistent), has returned, or has spread (advanced cervical cancer). Combination therapy is chemotherapy with or without the medicine bevacizumab.

Learn About KEYTRUDA® (pembrolizumab) Used Alone in Patients Who Were Previously Treated for Their Cervical Cancer

KEYTRUDA may be used alone when your cervical cancer has returned, or has spread or cannot be removed by surgery (advanced cervical cancer), and you have received chemotherapy, and it did not work or is no longer working.

KEYTRUDA alone or in combination helps to fight advanced cervical cancer

KEYTRUDA® (pembrolizumab) Is Helping to Fight Advanced Cervical Cancer
KEYTRUDA® (pembrolizumab) Is an Immunotherapy
Cancer Cell
Chemotherapy Kills Quickly Growing Cancer Cells
Chemotherapy

Immunotherapy
(KEYTRUDA)

Cancer
Cell

Chemotherapy

KEYTRUDA is a type of therapy called immunotherapy. Immunotherapy is different from chemotherapy. Instead of attacking cancer cells directly, immunotherapy helps your immune system do what it is designed to do: find and fight cancer cells. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.


Chemotherapy uses a drug to attack and kill quickly growing cancer cells directly. Chemotherapy can be used in combination with other drugs, such as immunotherapy, to treat advanced cancer. Chemotherapy may also damage normal quickly growing cells, such as hair and blood cells.

Bevacizumab works differently than chemotherapy. It blocks the growth of blood vessels which deliver oxygen and nutrients to tumors. This can slow or stop the cancer from growing by starving the tumor. You may receive treatment with or without bevacizumab based on your doctor’s assessment. You and your doctor will decide if bevacizumab is a part of your treatment.

Speak Openly and Ask Your Advanced Cervical Cancer Care Team Questions if You Have Them

Talking with your care team

Managing a cancer diagnosis comes with many challenges. Your care team members can provide the support you need. One of the most important jobs your doctors, nurses, and health advocates have is answering your questions. By speaking openly with your team, they can connect you to helpful resources that you need and deserve.

Questions you may ask to better understand what to expect:

  • Are there tools or resources that may help me during my treatment?
  • Are there services available to help with things like rides to appointments?
  • What can I expect from treatment as far as how I might look or feel?
  • How can I learn more about financial help?
Ask Your Friends and Family for Support During Your Advanced Cervical Cancer Treatment

Accepting support from loved ones

When you’re used to taking care of others, you could find it difficult to ask for assistance from family and friends.

Many people facing a cancer challenge find that asking for help with daily responsibilities can make things easier. Receiving help from loved ones and friends can allow you to focus on your health.

Most friends and family are happy to find out that there’s something they can do to help. They could organize meals, rides, or run errands while you’re at a doctor’s appointment. Their help could be as simple as a check-in phone call or a hug. Just be open about the kind of help you need.

More resources to help you throughout treatment:

Financial Help With KEYTRUDA® (pembrolizumab)

Financial help

Questions about insurance coverage or financial assistance? We can help.

Patient Support for KEYTRUDA® (pembrolizumab)

Patient support anytime, anywhere you need it

This program is designed to offer educational resources to help with the practical and emotional challenges of cancer. Patients prescribed KEYTRUDA for an approved indication can receive phone support, e‑mails, and online activities.

FDA-Approved Indications

KEYTRUDA is a prescription medicine used to treat a kind of cancer called cervical cancer that tests positive for "PD-L1."

  • KEYTRUDA may be used with chemotherapy medicines, with or without the medicine bevacizumab, when your cervical cancer does not go away (persistent), has returned, or has spread (advanced cervical cancer).
  • KEYTRUDA may be used alone when your cervical cancer:
    • has returned, or has spread or cannot be removed by surgery (advanced cervical cancer), and
    • you have received chemotherapy, and it did not work or is no longer working.

PD-L1 = programmed death ligand 1.

Important Safety Information

KEYTRUDA is a medicine that may treat certain cancers by working with your immune system. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen any time during treatment or even after your treatment has ended.

Call or see your health care provider right away if you develop any signs or symptoms of the following problems or if they get worse. These are not all of the signs and symptoms of immune system problems that can happen with KEYTRUDA:

Lung problems: cough, shortness of breath, or chest pain.

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); or bleeding or bruising more easily than normal.

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness.

Kidney problems: decrease in the amount of your urine; blood in your urine; swelling of your ankles; loss of appetite.

Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes.

Problems can also happen in other organs and tissues. Signs and symptoms of these problems may include: chest pain; irregular heartbeat; shortness of breath; swelling of ankles; confusion; sleepiness; memory problems; changes in mood or behavior; stiff neck; balance problems; tingling or numbness of the arms or legs; double vision; blurry vision; sensitivity to light; eye pain; changes in eyesight; persistent or severe muscle pain or weakness; muscle cramps; low red blood cells; bruising.

Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feeling like passing out, fever, and back pain.

Rejection of a transplanted organ. Your health care provider should tell you what signs and symptoms you should report and they will monitor you, depending on the type of organ transplant that you have had.

Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with KEYTRUDA. Your health care provider will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your health care provider will check you for these problems during treatment with KEYTRUDA. They may treat you with corticosteroid or hormone replacement medicines. They may also need to delay or completely stop treatment with KEYTRUDA if you have severe side effects.

Before you receive KEYTRUDA, tell your health care provider if you have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus; have had an organ transplant or have had or plan to have a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic); have had radiation treatment in your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.

If you are pregnant or plan to become pregnant, tell your health care provider. KEYTRUDA can harm your unborn baby. If you are able to become pregnant, you will be given a pregnancy test before you start treatment. Use effective birth control during treatment and for at least 4 months after your final dose of KEYTRUDA. Tell them right away if you think you may be pregnant or you become pregnant during treatment with KEYTRUDA.

Tell your health care provider if you are breastfeeding or plan to breastfeed. It is not known if KEYTRUDA passes into your breast milk. Do not breastfeed during treatment with KEYTRUDA and for 4 months after your final dose of KEYTRUDA.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Common side effects of KEYTRUDA when used alone include feeling tired; pain, including pain in muscles; rash; diarrhea; fever; cough; decreased appetite; itching; shortness of breath; constipation; bones or joints and stomach-area (abdominal) pain; nausea; and low levels of thyroid hormone.

In children, when KEYTRUDA is used alone, fever, vomiting, upper respiratory tract infection, headache, and low levels of white blood cells and red blood cells (anemia) are more common than in adults.

Common side effects of KEYTRUDA when given with certain chemotherapy medicines include feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble breathing; fever; hair loss; inflammation of the nerves that may cause pain, weakness, and paralysis in the arms and legs; swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; mouth sores; headache; weight loss; stomach-area (abdominal) pain; joint and muscle pain; and trouble sleeping.

Common side effects of KEYTRUDA when given with chemotherapy and bevacizumab include tingling or numbness of the arms or legs; hair loss; low red blood cell count; feeling tired or weak; nausea; low white blood cell count; diarrhea; high blood pressure; decreased platelet count; constipation; joint aches; vomiting; urinary tract infection; rash; low levels of thyroid hormone; and decreased appetite.

Common side effects of KEYTRUDA when given with axitinib include diarrhea; feeling tired or weak; high blood pressure; liver problems; low levels of thyroid hormone; decreased appetite; blisters or rash on the palms of your hands and soles of your feet; nausea; mouth sores or swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; hoarseness; rash; cough; and constipation.

These are not all the possible side effects of KEYTRUDA. Talk to your health care provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying Medication Guide for KEYTRUDA and discuss it with your doctor. The physician Prescribing Information also is available.