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Treatment Options With KEYTRUDA® (pembrolizumab) for Certain Patients With Kidney Cancer (Renal Cell Carcinoma)
Kidney cancer (RCC)

TREATMENT WITH KEYTRUDA

Adjuvant treatment for certain people with kidney cancer (RCC)

Even after surgery to remove kidney cancer (RCC), certain people may be at a higher risk of the cancer returning or spreading

If you’re at an intermediate-high or high risk of kidney cancer (RCC) returning after surgery, KEYTRUDA may be the next step to help reduce the chance of cancer coming back.

Where does kidney cancer (RCC) “recur” or come back?

When cancer comes back after surgery, it’s called recurrence. There are different types of cancer recurrence.

  • In local recurrence, the cancer has come back in the same place it first started
  • In distant recurrence, the cancer has come back in another part of the body

Want to know how your risk of kidney cancer (RCC) recurrence is determined?

Talk to your doctor about your pathology report to learn more about your risk level for kidney cancer (RCC) returning or spreading after surgery.

Dosing Options

KEYTRUDA is an option after surgery to help reduce the risk of kidney cancer (RCC) coming back for certain patients

KEYTRUDA is not chemotherapy or radiation therapy—it is an immunotherapy and it works with your immune system to help fight certain cancers.

KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Now that you’ve learned more about the risk of kidney cancer (RCC) coming back after surgery, you may be ready to explore a possible treatment option like KEYTRUDA.

Learn more about the results from a clinical trial.

Getting the support you need from your care team and loved ones

Your care team is made up of different health care providers who each play a big role in your treatment. These experts can aid you along your journey, answer questions, and offer guidance regarding your best path forward.

Your care team may include:

Urologist

Doctor with special training in urinary organs and male reproductive organs. This is likely the doctor who diagnosed your kidney cancer. 

Oncologist

Specialist in cancer and cancer treatment. Along with your surgeon, an oncologist will help develop the right treatment plan for you, including whether treatment after surgery is necessary.

Oncology nurses

Registered nurses with advanced training. These specialists work with patients who have cancer.

Dosing Options

If you have had surgery for your kidney cancer, ask your urologist or care team if a referral to an oncologist is right for you

Questions to ask your doctor about treatment after surgery

Taking an active role in your treatment plan after surgery can help you prepare for what comes next–and knowing what questions to ask can help you feel more confident in your future treatment discussions.

Consider asking your doctor questions like:

  • Am I at higher risk of my cancer coming back after surgery?
  • What is adjuvant treatment?
  • How does adjuvant therapy help reduce the chance of cancer coming back?
  • What are my treatment options after surgery?
  • How do I know if I should receive treatment after surgery?
  • What is KEYTRUDA and how does it work?
  • What are the risks and benefits of KEYTRUDA?

Writing down questions and taking notes when you meet with your doctor can help make your next conversation less overwhelming.

Patient support throughout your treatment

Patients who have been prescribed KEYTRUDA for an approved indication can access additional support from KEY+YOU, the patient support program for KEYTRUDA. KEY+YOU helps eligible patients by offering educational resources and support information throughout treatment.

FDA-Approved Indications

KEYTRUDA is a prescription medicine used to treat a kind of kidney cancer called renal cell carcinoma (RCC). KEYTRUDA may be used:

  • in adults with the medicine axitinib as your first treatment when your kidney cancer has spread or cannot be removed by surgery (advanced RCC).
  • alone if you are at intermediate-high or high risk of your kidney cancer (RCC) coming back after surgery to:
    • remove all or part of your kidney, or
    • remove all or part of your kidney and also surgery to remove cancer that has spread to other parts of the body (metastatic lesions).
Important Safety Information

KEYTRUDA is a medicine that may treat certain cancers by working with your immune system. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen any time during treatment or even after your treatment has ended.

Call or see your health care provider right away if you develop any signs or symptoms of the following problems or if they get worse. These are not all of the signs and symptoms of immune system problems that can happen with KEYTRUDA:

Lung problems: cough, shortness of breath, or chest pain.

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); or bleeding or bruising more easily than normal.

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness.

Kidney problems: decrease in the amount of your urine; blood in your urine; swelling of your ankles; loss of appetite.

Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes.

Problems can also happen in other organs and tissues. Signs and symptoms of these problems may include: chest pain; irregular heartbeat; shortness of breath; swelling of ankles; confusion; sleepiness; memory problems; changes in mood or behavior; stiff neck; balance problems; tingling or numbness of the arms or legs; double vision; blurry vision; sensitivity to light; eye pain; changes in eyesight; persistent or severe muscle pain or weakness; muscle cramps; low red blood cells; bruising.

Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feeling like passing out, fever, and back pain.

Rejection of a transplanted organ or tissue. Your health care provider should tell you what signs and symptoms you should report and they will monitor you, depending on the type of organ or tissue transplant that you have had.

Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with KEYTRUDA. Your health care provider will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your health care provider will check you for these problems during treatment with KEYTRUDA. They may treat you with corticosteroid or hormone replacement medicines. They may also need to delay or completely stop treatment with KEYTRUDA if you have severe side effects.

Before you receive KEYTRUDA, tell your health care provider if you have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus; have had an organ or tissue transplant, including corneal transplant, or have had or plan to have a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic); have had radiation treatment in your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.

If you are pregnant or plan to become pregnant, tell your health care provider. KEYTRUDA can harm your unborn baby. If you are able to become pregnant, you will be given a pregnancy test before you start treatment. Use effective birth control during treatment with KEYTRUDA and for 4 months after your last dose of KEYTRUDA. Tell them right away if you think you may be pregnant or you become pregnant during treatment with KEYTRUDA.

Tell your health care provider if you are breastfeeding or plan to breastfeed. It is not known if KEYTRUDA passes into your breast milk. Do not breastfeed during treatment with KEYTRUDA and for 4 months after your last dose of KEYTRUDA.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Common side effects of KEYTRUDA when used alone include feeling tired; pain, including pain in muscles; rash; diarrhea; fever; cough; decreased appetite; itching; shortness of breath; constipation; bones or joints and stomach-area (abdominal) pain; nausea; and low levels of thyroid hormone.

In children, when KEYTRUDA is used alone, fever, vomiting, headache, stomach area (abdominal) pain, and low levels of white blood cells and red blood cells (anemia) are more common than in adults.

Common side effects of KEYTRUDA when given with certain chemotherapy medicines include feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble breathing; fever; hair loss; inflammation of the nerves that may cause pain, weakness, and paralysis in the arms and legs; swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; mouth sores; headache; weight loss; stomach-area (abdominal) pain; joint and muscle pain; trouble sleeping; bleeding, blisters, or rash on the palms of your hands and soles of your feet; urinary tract infection; and low levels of thyroid hormone.

Common side effects of KEYTRUDA when given with chemotherapy with radiation therapy medicines include feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble breathing; fever; hair loss; inflammation of the nerves that may cause pain, weakness, and paralysis in the arms and legs; swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; mouth sores; headache; weight loss; stomach-area (abdominal) pain; joint and muscle pain; trouble sleeping; bleeding, blisters, or rash on the palms of your hands and soles of your feet; urinary tract infection; and low levels of thyroid hormone.

Common side effects of KEYTRUDA when given with enfortumab vedotin include rash; tingling or numbness of the arms or legs; feeling tired; itching; diarrhea; hair loss; weight loss; decreased appetite; dry eye; nausea; constipation; changes in sense of taste; and urinary tract infection.

Common side effects of KEYTRUDA when given with chemotherapy and bevacizumab include tingling or numbness of the arms or legs; hair loss; low red blood cell count; feeling tired or weak; nausea; low white blood cell count; diarrhea; high blood pressure; decreased platelet count; constipation; joint aches; vomiting; urinary tract infection; rash; low levels of thyroid hormone; and decreased appetite.

Common side effects of KEYTRUDA when given with axitinib include diarrhea; feeling tired or weak; high blood pressure; liver problems; low levels of thyroid hormone; decreased appetite; blisters or rash on the palms of your hands and soles of your feet; nausea; mouth sores or swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; hoarseness; rash; cough; and constipation.

These are not all the possible side effects of KEYTRUDA. Talk to your health care provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying Medication Guide for KEYTRUDA and discuss it with your doctor. The physician Prescribing Information also is available.